{"id":46,"date":"2016-11-14T20:25:38","date_gmt":"2016-11-14T18:25:38","guid":{"rendered":"http:\/\/pdc.vldlk.com\/en\/?page_id=46"},"modified":"2020-09-29T21:57:48","modified_gmt":"2020-09-29T18:57:48","slug":"our-services","status":"publish","type":"page","link":"https:\/\/pdc-eu.com\/en\/our-services","title":{"rendered":"Our Services"},"content":{"rendered":"<section class=\"l-section wpb_row height_medium\" id=\"sapatstvashta-diagnostika\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Companion diagnostic&#8221; font_container=&#8221;tag:h3|text_align:left|color:%23781518&#8243; use_theme_fonts=&#8221;yes&#8221;]<\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_4b3e29e8 via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-md-offset-1 vc_col-md-8 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Personalized therapy is a new medical approach that changes the maxim \u201cone size fits all\u201d to \u201cthe right treatment, the right patient, at the right time\u201d. This approach is based on innovations in areas such as functional genomic technologies, molecular diagnostics, data analysis, and real-time monitoring of conditions for better patient health care, identifying therapies to achieve the best results in disease management, or the identification of a predisposition to an illness.<\/p>\n<p>Providing companion diagnostics for the needs of personalized medicine is one of the core activities of ProDuCt.<\/p>\n<p>We offer the development of a logistical and diagnostic model for molecular research oriented to a particular target therapy. The service includes the collection and logistics of the biological material, providing the appropriate methodology, equipment and laboratory for the test, ensuring that CE IVD certified reagents are used and that they are compatible with the process. Moreover, we are sending the result to the treating physician. The model involves providing the required quality of research by building a network of certified laboratories.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_42077051 via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Therapeutic areas&#8221; font_container=&#8221;tag:h4|font_size:24px|text_align:left|color:%23b62025&#8243; use_theme_fonts=&#8221;yes&#8221;]<\/div><\/div><\/div><\/div><div class=\"w-tabs us_custom_16e570d6 layout_hor style_trendy switch_click has_scrolling\" style=\"--sections-title-size:1em\"><div class=\"w-tabs-list items_2 align_justify\" style=\"text-transform:uppercase;\"><div class=\"w-tabs-list-h\"><button class=\"w-tabs-item active\" aria-controls=\"content-d739\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Oncology<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-j93e\" aria-expanded=\"false\"><span class=\"w-tabs-item-title\">Infectious disease<\/span><\/button><\/div><\/div><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section active\" id=\"d739\"><button class=\"w-tabs-section-header active\" aria-controls=\"content-d739\" aria-expanded=\"true\"><div class=\"w-tabs-section-title\">Oncology<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-d739\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row us_custom_3145b60e via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-md-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Diagnostic service packages have been developed for:<\/p>\n<ul>\n<li>Non-small cell lung cancer<\/li>\n<li>Metastatic colorectal cancer<\/li>\n<li>Breast cancer<\/li>\n<li>Ovarian cancer<\/li>\n<li>Melanoma<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_af6a9b6a via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Biomarkers&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>Mutation analysis of the EGFR gene in patients with non-small cell lung cancer<\/li>\n<li>Detection of the presence or absence of mutations in the RAS (KRAS, NRAS) genes in patients with metastatic colorectal cancer<\/li>\n<li>Detection of the presence or absence of mutations in the BRAF gene in patients with melanoma and metastatic colorectal cancer;<\/li>\n<li>Immunohistochemical analysis of rearrangements in the ALK gene;<\/li>\n<li>Immunohistochemical assay for PD-L1 protein expression in patients with non-small cell lung cancer and urothelial carcinoma;<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Biological materials&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>Formalin-fixed and paraffin-embedded tumor tissue<\/li>\n<li>Venous blood (liquid biopsy)<\/li>\n<li>Urine (liquid biopsy)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"j93e\"><button class=\"w-tabs-section-header\" aria-controls=\"content-j93e\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Infectious disease<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-j93e\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The company has developed processes for the diagnosis and follow-up of infectious disease (ex. therapies for treating viral hepatitis C according to the genotype of the virus).<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_cf362e21 via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Processes&#8221; font_container=&#8221;tag:h4|font_size:24px|text_align:left|color:%23b62025&#8243; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><span lang=\"EN-US\">The work process managed by ProDuCt in the field of companion diagnostics includes full provision of the necessities for the development of a sustainable but also flexible patient program. This includes, but is not limited to:<\/span><\/p>\n<\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>Selection of laboratories<\/li>\n<li>Selection of qualified specialists<\/li>\n<li>Providing the necessary CE-IVD reagents for the analysis<\/li>\n<li>Preparation of all project documents<\/li>\n<li>Logistics of the patient\u2019s materials<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Contractors&#8221; font_container=&#8221;tag:h4|font_size:24px|text_align:left|color:%23b62025&#8243; use_theme_fonts=&#8221;yes&#8221;]<div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><table>\n<tbody>\n<tr>\n<td>Physicians and lab assistants from pathoanatomic laboratories<\/td>\n<td>21<\/td>\n<\/tr>\n<tr>\n<td>Nurses<\/td>\n<td>20<\/td>\n<\/tr>\n<tr>\n<td>Genetic laboratories<\/td>\n<td>7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_auto\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-separator size_custom with_line width_screen thick_1 style_solid color_border align_center with_content\" style=\"height:10px\"><div class=\"w-separator-h\"><i class=\"material-icons\">add_circle_outline<\/i><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_medium\" id=\"validacionni-prouchvania\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Validation studies&#8221; font_container=&#8221;tag:h3|text_align:left|color:%23781518&#8243; use_theme_fonts=&#8221;yes&#8221;]<\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-md-offset-1 vc_col-md-8 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><span lang=\"EN-US\">We at ProDuCt aim not only to provide the necessities for the implementation of the companion diagnostics but also to actively support the development of new, more sensitive and specific tests. We are involved in the validation of molecular tests, first of all by collecting samples from different patient populations (e.g. for the diagnosis of tuberculosis). Distances are irrelevant and we have sent samples to several continents.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_cf362e21 via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Topics in scope:&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;]<\/div><\/div><\/div><div class=\"vc_col-sm-8 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>Validation of non-invasive molecular diagnostic tests, based on \u201cliquid biopsy\u201d in the area of oncology<\/li>\n<li>Validation of a rapid diagnostic test for the diagnostics of tuberculosis infections<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_auto\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_middle type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-separator size_custom with_line width_screen thick_1 style_solid color_border align_center with_content\" style=\"height:10px\"><div class=\"w-separator-h\"><i class=\"material-icons\">add_circle_outline<\/i><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_medium\" id=\"klinichni-prouchvania\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Clinical trials&#8221; font_container=&#8221;tag:h3|text_align:left|color:%23781518&#8243; use_theme_fonts=&#8221;yes&#8221;]<\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 vc_col-md-offset-1 vc_col-md-8 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>The company operates as a Contract Research Organization (CRO) for the conduction of clinical trials for both medical products and medical devices. ProDuCt is being established more and more as a reliable partner of interested companies in the accomplishment of clinical trials, offering a full and complete process from the creation of the study protocol, obtaining the standpoint of the ethics committee, the passage of the monitoring visits and the completion of the study.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row us_custom_cf362e21 via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">[vc_custom_heading text=&#8221;Our competencies include:&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;]<\/div><\/div><\/div><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>Study design;<\/li>\n<li>Analysis and reporting of pre-clinical data;<\/li>\n<li>Protocol development;<\/li>\n<li>Case report form (CRF) design;<\/li>\n<li>Development of investigator brochures and integrated summaries;<\/li>\n<li>Site identification, pre-study feasibility;<\/li>\n<li>Overall project management, identification of potential problems;<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>Site monitoring and management, liaisons to the sites; site regulatory documents collection;<\/li>\n<li>Regulatory submission;<\/li>\n<li>Safety data review and reconciliation of adverse events and serious adverse events;<\/li>\n<li>Data management and statistical analysis of study data;<\/li>\n<li>Organization of trainings;<\/li>\n<li>Report writing etc.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"[vc_custom_heading text=\"Companion diagnostic\" font_container=\"tag:h3|text_align:left|color:%23781518\" use_theme_fonts=\"yes\"]Personalized therapy is a new medical approach that changes the maxim \u201cone size fits all\u201d to \u201cthe right treatment, the right patient, at the right time\u201d. This approach is based on innovations in areas such as functional genomic technologies, molecular diagnostics, data analysis, and real-time monitoring of conditions for better patient...","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-46","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/pages\/46"}],"collection":[{"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/comments?post=46"}],"version-history":[{"count":0,"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/pages\/46\/revisions"}],"wp:attachment":[{"href":"https:\/\/pdc-eu.com\/en\/wp-json\/wp\/v2\/media?parent=46"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}